Whoa. This may take a while.
I've used a lot of software and hardware to mix and record. Some good, some not. If you are going to do voice and have multiple mics in the same room I would go with a small mixer. If you will only have one mic on the computer you can just use a good USB microphone. Jim uses the Yeti and it's a good one.
http://www.bluemic.com/
If you are just mixing then you can use any software mixer you are comfortable with. I would start with Audacity. I'll just run down my steps on show 192 to see if that helps and then answer any questions.
I record the G+ Hangout with Garage Band on a Mac. I also capture my microphone only with Audio Hijack Pro. So I have two recordings going at once. Depending on the quality of Jim and John's recordings I'll either mix theirs with mine or use the master from Garage Band.
I remove noise with Audacity then export as a WAV file. Then I use Levelator to level all of our voices.
Re-import to Audacity and add the jingle track to front and back.
Export again as a WAV. Import to Adobe Soundbooth and export back out as MP3. I like Adobe's MP3's better than anything else I've tried. LAME encoder, iTunes, etc.
Then I tag it with MP3Tag, add album art, and then FTP it to Libsyn.
I can do all of this on Windows or Mac. I have both and have done it with both. If you are doing Skype there are a ton of options to capture Skype voices. It's much easier too. Piezio for Mac or Pamela for Windows. I like working with high bitrate files and then exporting down to the low grade MP3. Capture as high as you can. I prefer WAV. My files are over a gig in size each week but Jim and John capture to MP3 and they sound just fine. Just preference.
I would start getting to know Audacity. It's your best friend and test a lot!
Host of The Home Server Show Podcast.
Windows Home Server MVP - 2009 - 2012